Modeling of the photodynamic therapy process for the treatment of actinic keratoses

The post-doc's research will focus on the modeling of the photodynamic therapy process with the objective to increase efficiency and decrease pain. Some models reported in literature are based on the diffusion equation combined with an exponential decay for the photosensitizer concentration. Others models involves a series of chemical reactions for each sub-process such as photochemical reactions, diffusion and perfusion. In general, all the models enable an estimation of the necrosis by a threshold of the singlet oxygen concentration and therefore a measure of efficiency. Nonetheless, no model take account of the pain.

The main objectives of the post-doc's research are to:

  • Identify and integrate the most appropriate modeling
  • Best understand pain